Pharmalot Columnist, Senior Writer Ed covers the pharmaceutical industry. Ed Silverman Pharmalot Pharmalittle: Insulin study causes a big flap; Glaxo gets a reprieve thanks to a Novartis setback Rise and shine, everyone, another busy day is on the way. Our journey is made more tolerable today thanks to a bright and shiny sun enveloping the otherwise chilly Pharmalot campus. To keep warm, yes, we are quaffing a few welcome cups of stimulation, alternating between peppermint mocha and blueberry. Feel free to join us. What have you got to lose? Meanwhile, here are some tidbits. Hope you have a smashing day and, as always, we would like to remind you that we accept tips, encrypted messages, and secret dossiers from overseas …Preliminary research suggesting some diabetes patients may be injecting medicine that has partially disintegrated is causing concern even as serious questions are raised about the research itself, the Associated Press writes. The study author, a pharmacist, bought 18 vials of insulin at several pharmacies and found, on average, the vials had less than half of what was listed on the label and none met a minimum standard. But the methods used to test the insulin are being questioned, and insulin makers, patient advocate groups, and diabetes experts say patients would be getting sick if the findings were accurate. The study was published in the Journal of Diabetes Science & Technology. Unlock this article by subscribing to STAT+ and enjoy your first 30 days free! GET STARTED [email protected] About the Author Reprints Daily reporting and analysis The most comprehensive industry coverage from a powerhouse team of reporters Subscriber-only newsletters Daily newsletters to brief you on the most important industry news of the day STAT+ Conversations Weekly opportunities to engage with our reporters and leading industry experts in live video conversations Exclusive industry events Premium access to subscriber-only networking events around the country The best reporters in the industry The most trusted and well-connected newsroom in the health care industry And much more Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr. By Ed Silverman Feb. 8, 2018 Reprints GET STARTED @Pharmalot STAT+ is STAT’s premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond. Alex Hogan/STAT What is it? What’s included? Log In | Learn More Tags gene therapyopioidspharmaceuticalspharmalittlepolicySTAT+
Email Scientists from Royal Holloway, University of London and UCL have identified how a specific diet can be used to help treat patients with uncontrolled epilepsy.The findings, which reveal how the ketogenic diet acts to block seizures in patients with drug-resistant epilepsy, are published November 25 in the journal Brain.Epilepsy affects over 50 million people worldwide and approximately a third of people diagnosed with epilepsy do not have seizures adequately controlled by current treatments. Share Pinterest Share on Facebook Share on Twitter LinkedIn The research team have identified a specific fatty acid, decanoic acid, provided in the MCT (medium chain triglyceride, a chemical containing three fatty acids) ketogenic diet that has potent anti-epileptic effects. The diet comprises of high levels of fat and low levels of carbohydrate-containing foods.“By examining the fats provided in the diet, we have identified a specific fatty acid that outperforms drugs currently used for controlling seizures, and that may have fewer side effects,” said Professor Robin Williams from the Centre for Biomedical Sciences at the School of Biological Sciences at Royal Holloway.“This discovery will enable us to develop improved formulations that are now likely to significantly improve the treatment of epilepsy. It will offer a whole new approach to the management of epilepsies in children and adults,” added Professor Matthew Walker from UCL’s Institute of Neurology.“Finding that the therapeutic mechanism of the diet is likely to be through the fat, rather than widely accepted by generation of ketones, may enable us to develop improved diets, and suggests we should re-name the diet simply ‘the MCT diet’” said Professor Williams.Professor Walker is supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre.The research is funded by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), who support projects with a potential to minimise the use of animals in research, and by Vitaflo international Ltd, who are committed to developing improved treatments for people with drug resistant epilepsy. The project builds on work in which most of the animal use in epilepsy research has been replaced by the simple amoeba to initially screen and identify improved treatments.
The Raising Superheroes support group explores families’ strengths and weaknesses. A Heideveld family centre has received a R100 000 donation from a big chain store.Arise, a non-profit organisation, helps strengthen families and place children in loving homes. It provides counselling as well as family- and adoption-support programmes. In one case, director Danielle Moosajie explained, the organisation had helped a grandmother and her grandson, who was misbehaving and failing at school.“The boy had no relationship with his father and mother who were in and out of prison. Arise placed them within a group support six-week programme where they learnt about the strength that they hold.”The support group takes its lead from the strengths and weaknesses of superheroes.“In that way kids can identify because they are the experts in superheroes,” Ms Moosajie said. She said the grandson was now motivated to go to school, and the family realised what changes it needed to make. “That relationship really grew stronger,” she said.In another case, a mother, who had suffered abuse, had struggled to give her child physical attention, but after therapy, she had hugged her 10-year-old son for the first time.Ms Moosajie said Arise helped families enjoy family time and not just watch television. Parents discovered things about their children they hadn’t known such as their favourite colour or what they loved most about them.She said it was hard asking Cape Flats parents to look at life positively as they were often just trying to make ends meet and felt added stress when a child started acting out or didn’t want to go to school.“Parents learn to stop just living according to survival mode and actually live a nurturing meaningful life with their children. As parents, you need to put effort into your child’s life and not just depend on doctors and therapists,” she said. Call 021 633 4058 or email [email protected] for more information.
The innovations in Endpoint IC technology leverage both Moore’s Law and other leading-edge semiconductor advancements in order to improve IC performance and functionality.New Endpoint IC Series Delivers 2x More Chips Per Silicon WaferThe new Impinj M700 series of endpoint ICs leverage these innovative IC technologies to enable 300 mm silicon wafers with more than twice as many ICs per wafer as any other RAIN RFID manufacturer’s 300 mm wafers, and more than four times as many as any using 200 mm wafers. The M700 series ICs are so small that roughly 30 million of them will fit in a single coffee cup.The Impinj M700 series of endpoint ICs enhances the Impinj platform, comprising RAIN RFID endpoints, connectivity, and software. Organizations around the world use the Impinj platform to connect items to applications, enabling the Internet of Things. Impinj endpoint ICs have already enabled connectivity for more than 30 billion everyday items including retail apparel, airline luggage, manufacturing equipment, and logistics items allowing businesses to make smarter decisions, improve customer experience, and drive sales.Impinj will demonstrate the first chips in the Impinj M700 series to select partners and customers at RFID Journal Live from April 2-4, 2019. Impinj, a leading provider, and pioneer of RAIN RFID Solutions, has introduced new endpoint IC technologies to meet the increasing demand for item connectivity in the retail, grocery, consumer packaged goods, and logistics markets. An Endpoint comprises of an Impinj tag chip attached to an individual item, providing a unique identifier and enabling connectivity devices to determine the item’s identity, location, and authenticity.Developed in an advanced semiconductor process node, these technologies paint the future of RAIN RFID by endowing Impinj endpoint ICs with differentiated features and enhanced performance, enabling these and other emerging markets in the coming years.Impinj’s pioneering IC technologies improve readability and add new features and functionality to: Increase the distance, reliability, and speed at which a RAIN RFID system can inventory, locate, and engage items Enable key RAIN RFID use cases like item authentication, loss prevention, frictionless point-of-sale, and shipment verification Allow Impinj’s inlay partners to design smaller, high-performing, truly global RAIN RFID tags
Mr Doyle, aged 94, won the weekly rollover jackpot prize which starts at £500 and increases by £200 each week which it is not won. He has been a member of City’s official lottery scheme since its conception, Mr Doyle, whose daughter and grandson were presented with a cheque for the sum of £4700 on his behalf, told the Foundation that he was absolutely “thrilled”In addition to the weekly jackpot rollover, there are also five prizes of £20 and one £50 prize, as well as a monthly jackpot of £500 and signed City memorabilia.All Robins Lotto members are automatically entered into the weekly draws and gain access to a number of exclusive Robins Lotto events.Take a chance, make a changeAll proceeds of the Robins Lotto go directly towards supporting the fantastic community work carried out by City’s official charity.To find out more about becoming a Robins Lotto member click here or call 0117 963 0636.Become a member today
iStock/Thinkstock(NEW YORK) — Here are the latest scores and winners:INTERLEAGUESan Diego 7, Detroit 3 AMERICAN LEAGUETexas 8, N.Y. Yankees 1Oakland 10, Chicago White Sox 2Kansas City 3, Toronto 2Minnesota 4, Cleveland 2Baltimore 8, Tampa Bay 3L.A. Angels 6, Boston 3Houston 5, Seattle 2NATIONAL LEAGUEWashington 18, Cincinnati 3Chicago Cubs 5, Miami 3Atlanta 3, Milwaukee 1Pittsburgh 7, St. Louis 3N.Y. Mets 5, San Francisco 2L.A. Dodgers 4, Colorado 0Arizona 9, Philadelphia 2WOMEN’S NATIONAL BASKETBALL ASSOCIATIONL.A. Sparks 84, Indiana 73Copyright © 2017, ABC Radio. All rights reserved.Powered by WPeMatico Related
Chonburi’s disabled athletes did the region proud by finishing top of the medals table at the recently completed 29th National Games for People with Disabilities. Mirroring the National Games, held at the back end of last year, Chonburi was also the host for the disabled games held from January 23-27, and the home athletes achieved unparalleled success, winning 106 gold medals, 78 silver and 80 bronze medals for a total of 264 in all.Wichit Chatpaisit, the Governor of Chonburi, summarizes the sports competition results during the closing ceremony. Coming in second place was the Bangkok Sports Association, receiving 90 gold medals, 53 silver and 38 bronze medals (a total of 181), and in third was the Nonthaburi Sports Association team who garnered 64 gold medals, 57 silver and 42 bronze, for a total of 163 medals.These three teams were trailed in next by the Pathumthani Sports Association (63 medals) and the Lopburi Sports Association (56 medals) respectively.The athletes took part in some 17 different sporting disciplines and teams from 67 Provincial Sports Associations from all over the country took part.The final closing ceremony was held on January 27 at the National Eastern Region Indoor Stadium in Pattaya and was attended by Dhiravat Sirivansant (Assistant Minister of Tourism and Sports) who oversaw the handing over of the Games flag to representatives from Khon Kaen for the 30th edition to be held next year.Kanokpan Julkasem (Director of the Sports Authority of Thailand) offered congratulations to all the competing athletes and praised the Chonburi inhabitants and organizers for doing such a sterling job in hosting a very successful event.As well as song and dance routines and a parade of athletes representing all the competing regions, one particular highlight of the closing ceremony was a live song without music, “Hua Jai Puk Kan”, led by Jenjira Suksud (with a fabulous singing voice) from the Karunyawet Welfare House for People with Disabilities. The flame was slowly extinguished as the song ended in a fitting way to end a tremendously successful event for the Chonburi region.The Khon Kaen Province representatives join the closing parade as the host of the 30th Games for people with disabilities, to be held next year.Competitors take part in the shooting event.The archery competition was held at the Public Park in front of the National Eastern Indoor Stadium in Pattaya.A keenly contested basketball match.Blind Futsal was a new event introduced at these games.Action at the games swimming pool.A runner heads for the finish line and gold medal glory.Athletes take part in the wheelchair sprints.Jenjira Suksud sings “Hua Jai Puk Kan” as the games torch is slowly extinguished to officially close the competition.Chonburi’s Peerapong Bungbok, seated center, celebrates his gold medal success in the Men’s R1 Air Rifle category.
By Mitchell Clarke More than 200,000 people have signed a petition to Cardinia Shire Council to save a Staffy that was involved in…[To read the rest of this story Subscribe or Login to the Gazette Access Pass] Thanks for reading the Pakenham Berwick Gazette. Subscribe or Login to read the rest of this content with the Gazette Digital Access Pass subscription.
The Nelson Leafs has narrowed the field to selecting a successor to former skipper Frank Maida.According to a person close to the selection process, the Kootenay International Junior Hockey League squad has boiled the long list of applicants down to four candidates. It is believed that all four candidates are all from outside the Nelson area.The final decision is now in the hands of the Leafs’ executive.Maida decided to tender his resignation following the 2013-14 season.Nelson hosted the 2014 Cyclone Taylor Cup; won by Murdoch Division rival Beaver Valley. The Nitehawks went on to win the Keystone Cup, emblematic of Western Canada Junior Hockey supremacy.Nelson finished fourth at the Cyclone Taylor Cup and was the only team to take points from eventual champion Beaver Valley — playing to a 2-2 tie against the Nitehawks during the round robin in one of the best played games in brief history of the NDCC Arena.Unfortunately, Maida, finishing with an overall record of 109-53-3-11, was unable to coach Nelson past the second round of the Murdoch Division playoffs, losing once to Castlegar and twice to Beaver Valley — the eventual KIJHL champs the past three seasons.Leaf president Russell Stocks also resigned his position but will stay on as past president to allow the Heritage City franchise to make a smooth transition this upcoming season at the executive level.
On a chilly night at Jaycees Field, in which the first pitch temperature was just 34 degrees, Washington State struck first, using a pair of walks and an SFA error to take a 1-0 lead after the top of the first. The Cougars extended that advantage to 2-0 in the third off an RBI single to left – the first of WSU’s two hits.SFA rallied with a run in the bottom half of the third as Dan O’Neill reached on a throwing error by the Cougar third baseman, allowing Matthew Dickey to score from third. That advantage stood until the sixth when Washington State used a two-RBI double to right to push across the tying and winning runs. The Lumberjacks mounted one last rally in the eighth, loading the bases off a single from Tyler Boxwell, a double from Eric DeJesus and a Dickey walk. But Conner Fikes lined out on a hard hit ball to center, ending the SFA threat. Washington State 4, Stephen F. Austin 3 The game capped the 2015 SFA Tipton Ford Baseball Classic at Jaycees Field and the Lumberjacks’ four-game season-opening homestand. The ‘Jacks now head on the road for the next four, beginning Tuesday evening when SFA heads to College Station to battle 22nd-ranked Texas A&M at Olsen Field. First pitch is scheduled for 6:30 p.m. The Lumberjacks then took the lead in the bottom of the fourth off a pair of runs, the first of which came on an RBI blooper to right from Will Vest. With runners at the corners, SFA then successfully pulled off the double steal as Vest distracted the Cougar pitcher long enough for Anthony Soriano to slide home, giving the ‘Jacks the 3-2 lead. NACOGDOCHES, Texas – A late inning rally once again came up just short as Stephen F. Austin closed out the 2015 Tipton Ford Classic with a 4-3 loss to Washington State at Jaycees Field. The loss drops SFA to 1-3 on the year while the Cougars improved to 2-2. Starter Patrick Day went 3.0 innings in his collegiate debut, allowing two runs (one earned) with one hit and five strikeouts. Chris Hassold (0-1) was tagged with the loss after going 2.1 innings and allowing two earned runs on one hit and four strikeouts. Once again, the SFA bullpen was solid, allowing no Cougar hits over the final 3.1 innings with six strikeouts. The loss came despite the fact the Lumberjacks allowed just two Washington State hits all night, but both hits accounted for Cougar runs. The ‘Jack pitching staff gave up 11 walks on the night as well, helping the Cougars push across enough runs to get the victory. Nick Ramos led the way offensively for SFA, going 3-for-4 on the night. Four other Lumberjacks recorded hits with Vest notching the lone RBI on the night for the ‘Jacks.