Major cause of dementia discovered in the brain

first_imgLinkedIn Pinterest The team consists of scientists from The University of Manchester, the University of Auckland, AgResearch New Zealand, the South Australian Research and Development Institute, Massachusetts General Hospital and Harvard University.The latest paper by the scientists, published today in the Proceedings of the National Academy of Sciences, shows that Huntington’s Disease – one of seven major types of age-related dementia – is directly linked to brain urea levels and metabolic processes.Their 2016 study revealing that urea is similarly linked to Alzheimer’s, shows, according to Professor Cooper, that the discovery could be relevant to all types of age-related dementias.The Huntington’s study also showed that the high urea levels occurred before dementia sets in, which could help doctors to one day diagnose and even treat dementia, well in advance of its onset.Urea and ammonia in the brain are metabolic breakdown products of protein. Urea is more commonly known as a compound which is excreted from the body in urine. If urea and ammonia build up in the body because the kidneys are unable to eliminate them, for example, serious symptoms can result.Professor Cooper, who is based at The University of Manchester’s Division of Cardiovascular Sciences, said: “This study on Huntington’s Disease is the final piece of the jigsaw which leads us to conclude that high brain urea plays a pivotal role in dementia.“Alzheimer’s and Huntington’s are at opposite ends of the dementia spectrum – so if this holds true for these types, then I believe it is highly likely it will hold true for all the major age-related dementias.“More research, however, is needed to discover the source of the elevated urea in HD, particularly concerning the potential involvement of ammonia and a systemic metabolic defect.“This could have profound implications for our fundamental understanding of the molecular basis of dementia, and its treatability, including the potential use of therapies already in use for disorders with systemic urea phenotypes.”Dementia results in a progressive and irreversible loss of nerve cells and brain functioning, causing loss of memory and cognitive impairments affecting the ability to learn. Currently, there is no cure.The team used human brains, donated by families for medical research, as well as transgenic sheep in Australia.Manchester members of the team used cutting-edge gas chromatography mass spectrometry to measure brain urea levels. For levels to be toxic urea must rise 4-fold or higher than in the normal brain says Professor Cooper.He added: “We already know Huntington’s Disease is an illness caused by a faulty gene in our DNA – but until now we didn’t understand how that causes brain damage – so we feel this is an important milestone.“Doctors already use medicines to tackle high levels of ammonia in other parts of the body Lactulose – a commonly used laxative, for example, traps ammonia in the gut. So it is conceivable that one day, a commonly used drug may be able to stop dementia from progressing. It might even be shown that treating this metabolic state in the brain may help in the regeneration of tissue, thus giving a tantalising hint that reversal of dementia may one day be possible.” An international team of scientists have confirmed the discovery of a major cause of dementia, with important implications for possible treatment and diagnosis.Professor Garth Cooper from The University of Manchester, who leads the Manchester team, says the build-up of urea in the brain to toxic levels can cause brain damage – and eventually dementia.The work follows on from Professor Cooper’s earlier studies, which identified metabolic linkages between Huntington’s, other neurodegenerative diseases and type-2 diabetes. Share on Facebookcenter_img Share Email Share on Twitterlast_img read more

Self Help Seeks Community Support During Pandemic

first_imgBy Kirsten LaskeyLos Alamos Daily Postkirsten@ladailypost.comIn times of hardship, Self Help, Inc., is there to lend a helping hand to those in need. With the COVID-19 pandemic growing and with it an increasing number of significant impacts, local non-profit Self Help is looking for some assistance itself.Self Help Executive Director Maura Taylor said the nonprofit’s budget allows it to help 500 families a year or a little more than 1,000 individuals. However, the COVID-19 pandemic is expected to increase the demand for the nonprofit’s services and Taylor encourages the community to help aid its efforts by donating financially.She said the organization has a strong number of volunteers so it’s overhead expenses are not expected to rise, which means donations can directly benefit clients.Taylor added that the organization works to stretch every dollar it has.“We can really change a life for $30,” she said.Taylor said one of the most common things Self Help assists with is preventing evictions and stopping utilities from being shut off. But its services are widespread; it can help with groceries and food vouchers as well as assist people in getting a cell phone and paying court fees.While the hope is the government will step in with aid, Taylor said she is concerned the most vulnerable: the low income, the undocumented and other individuals, will slip through the cracks.“What I’m hoping for is widespread government officials to minimize the effects,” she said. “We definitely expect an increase in need…”The number of calls is already growing, Taylor said.To donate, visit or send a check payable to Self Help, Inc., 2390 North Road, in Los Alamos. All donations are tax deductible.Taylor said Los Alamos is a great community that offers a lot of support.“We are lucky to have such a great, supportive community … there’s a lot of nervous energy and there hasn’t been a whole lot of places to put that energy but this is one place it can go,” she said.She added that it is times like this that people really come together and help one another.“I think it is so easy to get really fearful … I think the best thing about times like this is that humanity bonds together,” Taylor said. “I really believe our community can really support people who are on the edge … and help support their neighbors.”Self Help is headquartered in Los Alamos but along with the Hill, it serves Taos County, a portion of Santa Fe County and Rio Arriba County. Taylor said the area the organization covers is about the size of New Hampshire. The organization recently celebrated its 50th anniversary and the state and local government honored Self Help by proclaiming Oct. 15, 2019 as Self Help Day.Staff are operating remotely but are still available by phone, 505.662.4666 or visit read more

EP seeks partner for Hattersley redevelopment

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MulteFire Alliance Completes Its IoT Optimized Specification

first_img Adds eMTC-U support for moderate data rate applications in the global 2.4 GHz unlicensed band Adds NB-IoT-U support for narrowband applications in the regional 800/900 MHz unlicensed bands Adds MulteFire 1.9 GHz support (for the unlicensed part in 3GPP defined Band 39), also known as sXGP in Japan, which is ready for commercial deployment in Japan with support from the XGP Forum and an ecosystem of TD-LTE devices in place that support Band 39 today Enhanced MulteFire 1.0 Broadband Services in the Global 5 GHz Unlicensed Band: The Release 1.1 specification will be published to MulteFire Alliance members in January 2019 and will be made available for download by anyone with an interest in MulteFire technology by mid-year.Visit the MulteFire Alliance to learn more about this technology. The MulteFire Alliance has completed the Release 1.1 specification for MulteFire Technology. Multefire is a technology that allows simple deployment of LTE in the unlicensed or shared spectrum. The new specifications, according to the international consortium, are optimized for IoT. Adding support for eMTC-U and NB-IoT-U, as well as support for additional spectrum bands, the Release 1.1 specification delivers more robust wireless network capabilities for Industrial IoT and Enterprises to meet their specific requirements for performance, latency, security and mobility.According to Asimakis Kokkos, Head of the Technical Specification Group of the Alliance, MulteFire 1.0 is a novel technology that was designed to create new wireless networks by operating LTE-based technology standalone in unlicensed or shared spectrum bands. MulteFire 1.1 takes the potential of this technology even further by improving on the performance of MulteFire 1.0 for the global 5 GHz unlicensed band, and by adding new capabilities and support for additional spectrum bands.The MulteFire Release 1.1 specification includes the following features:Added Additional Spectrum Bands Focusing on IoT and Expanded IoT Services with Low Power Wide Area Support: Delivers more robust mobility in up to 50 km/h speeds with the addition of Autonomous UE Mobility (AUM) which performs autonomous handover without explicit network command Allows for faster uplink data transmissions with Grant-less Uplink (GUL), whereby the UE can start transmitting immediately Supports improved downlink coverage with Wideband Coverage Enhancements (WCE) Adds Self-Organizing Networks (SON) capabilitieslast_img read more

ESPN’S John Clayton Says Johnny Manziel’s Time in Cleveland is Over

first_img Related TopicsJohn ClaytonJohnny Manziel Matt Loede has been a part of the Cleveland Sports Media for over 21 years, with experience covering Major League Baseball, National Basketball Association, the National Football League and even high school and college events. He has been a part of the Cleveland Indians coverage since the opening of Jacobs/Progressive Field in 1994, and spent two and a half years covering the team for 92.3 The Fan, and covers them daily for Associated Press Radio. You can follow Matt on Twitter HERE. Matt Loedecenter_img According to one NFL insider, the end of the Johnny Manziel era in Cleveland will end on Sunday when the Browns finish a horrible season at home against the Steelers.John Clayton of ESPN reports that he thinks Manziel is done as far as his tenure in Cleveland goes, stating the following in a segment on ‘SportsCenter’: “I think he’s over, I really do, because the team now is in a position to draft — most likely — the first quarterback in the draft, and whatever they do, and if they do take a quarterback, you know that they’re not going to stay with Johnny Manziel.“They’ll try to flip him for a low draft choice – fifth-round, sixth-round pick – Dallas would be a likely destination, but I think you can understand that there’s disappointment with the way this all worked out.”Here’s the video of Clayton on Manziel, who won’t play Sunday against the Steelers due to a concussion. last_img read more

High School Hockey: Olmsted Falls Clinches White North Title Following 8-5 Comeback Win Over Bay

first_img Related TopicsBayOlmsted Falls Matt Loede Matt Loede has been a part of the Cleveland Sports Media for over 21 years, with experience covering Major League Baseball, National Basketball Association, the National Football League and even high school and college events. He has been a part of the Cleveland Indians coverage since the opening of Jacobs/Progressive Field in 1994, and spent two and a half years covering the team for 92.3 The Fan, and covers them daily for Associated Press Radio. You can follow Matt on Twitter HERE.center_img The Olmsted Falls Bulldogs will enter Baron Cup play on Tuesday on a high note, as they overcame a four-goal deficit Saturday to top the Bay Rockets 8-5.The win means that Olmsted Falls wraps up the year at 9-1 in GCHSHL White Division play, and they also are going to enter Baron Cup play in Brooklyn Tuesday against Avon as the number two seed.The Rockets on Saturday led the Bulldogs early 1-0, and 2-1 after the first period. They continued to build their lead, and went up 5-1 before the Bulldogs began their comeback.The first goal to cut it to 5-2 was a penalty shot by Jacob Kerkay, and then he struck again later to make it 5-3, scoring on a power play goal with six minutes to play in the second period.The Bulldogs got it to 5-4 on a goal from freshman Brady Fitzpatrick with an assist from Dominic Conte, which also was the score at the end of two.Kerkay tied the game at five in the third as he scored again, this third goal of the day to even up the score with the Rockets.With 7:19 left in the third the Bulldogs took the lead for good, as Fitzpatrick scored to complete the comeback and give Olmsted Falls the lead.Zach Henley got in on the action for the Bulldogs to make it a 7-5 lead, and the scoring was completed as Conte came through with a short-handed goal to end the affair at 8-5. The Bulldogs will wrap up the regular season on Sunday at 12:50 at OBM Arena as they will take on Strongsville. The Rockets fall to 5-5 in White North play in the GCHSHL with the setback. last_img read more

Q&A: Graham Rahal on rising popularity and driving for Honda

first_imgDespite driving for a single-car team that is going through some growing pains with Honda, Graham Rahal is fifth in the Verizon IndyCar Series points going into Toronto this weekend. Rahal spoke about keeping a positive attitude, having David Letterman as a team co-owner and driving a minivan around the Nurburgring with Chris Jenkins, Special for USA TODAY Sports.Graham Rahal (Thomas J. Russo, USA TODAY Sports)Graham Rahal (Thomas J. Russo, USA TODAY Sports)Q: How would you assess your season so far?Rahal: “I think the team has done an excellent job this year. They are the biggest part of the recent success, I think that’s the truth at this point. A lot of people give me the credit, but the guys have made this happen. I think the teamwork, the camaraderie, the mindset of everybody has been what’s transferred into work ethic. The guys have worked a lot harder, a lot better, together and that’s made the difference this year.”Q: So you’ve obviously been up front and open about the challenges you guys are facing with being affiliated with Honda. But in terms of how you go about your business, how the team goes about its business, you have to maintain a positive attitude through it all, right? GR: “Oh, for sure. And look, I think a lot of people have been very critical, very hard on Honda. I really do have the utmost confidence in them, in what they do and the people that they have around them. I think without a doubt, we keep a positive mindset but I think there’s a reason for it. Maybe we haven’t had it easy at times this year. But I know Honda, all those guys have got their heads down working hard to improve as much as we can.”Q: Do you see reasons to expect improvement this season, or is it more of a long-term thing?GR: “No, I think it’s more of a long-term process. Maybe we could see some improvement. We’re already just past halfway,  I think, in this season so I don’t know that you’re going to see a ton of improvement just due to time. But our team, we made a big mistake at Texas that we’ll learn from and our team can continue to improve. That can also really help us.”HONDA: Isn’t seeing any IndyCar oval payoffQ: The idea that you guys are a smaller team, and there’s the affiliation with Honda, but you’re still fifth in the points. Is that a source of pride for you guys right now?GR: “It is. It is, but I have high expectations. And yeah, there’s a lot of pride involved and I’m focused right now toward catching what’s ahead of us and not looking back. I’m disappointed in our performance in Texas. We found that we probably left around 200 pounds of downforce on the table compared to the top-running Honda cars — 200 pounds is a lot of downforce, and we have to make sure that we don’t do that next time. We live and we learn. But there is a sense of pride, and I think that we are only going to get better. We have to believe that our potential is huge, and we’re going to try to fulfill that over the next few races.”Q: So when you were a kid interested in racing, I’d imagine it was about having fun and going fast. Then as you get older, you realize that there’s this whole business side to racing. How did that change the way you view racing? Is it frustrating at times that there are sometimes things that are out of your hands that prevent you from doing what you want to do?GR: “Well, racing has its good and its bads. There’s a lot of work that goes into it. One of my good friends, a buddy of mine is Tyron Smith from the Cowboys, I was explaining to him last week, I said, look, the thing about racing that’s so difficult is that we are solely dependent on sponsors. Unlike the Cowboys, if Miller Lite doesn’t sponsor the Cowboys, they’re still going to play football. If Steak and Shake doesn’t sponsor me, I don’t go racing. It’s a different mentality than any other sport. It is frustrating at times, but I’ve always been somebody who’s enjoyed the challenge of that, enjoyed the challenge of finding sponsorship and working hard on it off the track. I think it’s cool. It is difficult, for sure.”Q: When younger racers come to you for advice, is that something you try to open their eyes to? That there is more to this than they might think? GR: “For sure. I mean, a lot of guys look at me and think, ‘Well, he’s a Rahal, so it comes easy.’ The truth is, it’s anything but. It’s something that I’ve worked very hard in recent years to find that sponsorship and do those things. I tell all the young guys, the Conor Dalys of the world, that it doesn’t matter what your name is. There’s a hell of a lot of good drivers out here. A lot. And what’s going to separate you from the others is how you work off the track. Because there are a lot of guys who are going to be able to get in the car and be able to go fast. But there’s not a lot of guys who are fully rounded, can help find the sponsorship and make it all work.”Q: So when you were at the Indy 500, during driver introductions, it seemed like you got one of the biggest ovations of anyone. I don’t know if you’re so focused at that point that you block it out, but do you have a sense of your popularity and how people have rallied behind you?GR: “Well, I think this year people have rallied behind me, and I really appreciate it. I’m trying so hard to make everybody proud — that’s the truth. I’m trying so hard to help build this sport. And I know that my performance does have an influence on that. And so I’m trying. It was really cool, obviously, to have a good result at Indy. I can’t wait to get back there next year, I think we have a good starting point versus coming from where we were last year, the setup for this year, I don’t think we had a whole lot of understanding of where we’d be this season. And I think by the end of the month we had a good starting point. I’m excited to get back there and give it a shot.”Q: So now that David Letterman is retired from the late-night talk show game, is he around more?GR: “Well, he hasn’t been. But I have heard from him more via email, and I think he wants to be. I think he does, and I think we will see him. So far, not much, but we’re only a couple of weeks into that.”Q: What’s it like to drive for him?GR: “It’s cool. I’ve been spoiled to drive for him and Paul Newman, and both those guys are just so passionate about this sport. And it’s refreshing to see people who are such huge celebrities that find IndyCar racing so spectacular. That’s what I love about it, more than anything else.”LETTERMAN: Talk show host gave IndyCar another platform Q: So Toronto is up next. What should fans know about the challenges you guys face there?GR: “It’s very challenging. That course has so many different types of pavement, concrete, bumps, mid-corner bumps. It’s one of the most difficult tracks to get a good handle on. It’s probably the track with literally zero margin for error. If you make a mistake there, you’re finding yourself in the concrete wall right away. I think that’s what’s cool about it. But I have huge expectations for our team, and we’ve had good runs on road courses lately and I’m definitely excited to get out there and give it a shot in Toronto.”SPEED ROUNDQ: Favorite track you’ve ever raced on?GR: “Road America. Road America is spectacular.”Q: Would love to see it back on the schedule, I’d imagine?GR: “Oh, yeah. One place, that would be it.”Q: One track you’ve never raced on that you’d like to try? GR: “Probably Spa over in Europe. I think Spa is one of those tracks that everybody wants to race there. Road America is our Spa. I’d love to go try it out. I’ve been there before. When we raced in Europe, I went and drove by it. And I’ve been around the Nurburgring, it wasn’t a race but I’ve been around it.”Q: What did you drive around the Nurburgring?GR: “A minivan.”Q: And you’re getting passed by Porsches and things like that?GR: “Yeah, but it was just fun.”Q: First street car you ever owned?GR: “A 2004 Subaru WRX STI.”Q: Not bad!GR: “Yeah, it was an absolute blast. I loved it.”Q: Favorite city in the world?GR: “Truthfully, I’m from Columbus, Ohio. And I love Columbus, Ohio. But actually, San Francisco. I really like San Francisco. Tokyo is really cool, too.”Q: Kind of cool that you guys get to travel to different places as part of this job?GR: “It’s awesome. I was going to say, I love Toronto. It’s a really cool city, really cool people. One of the perks of the job, the traveling is no fun but at least when you get there, when the traveling’s over and you actually get to where you’re supposed to be, there are some cool places that you get to go and see.”Q: Final question: If you weren’t a race car driver, what would you be doing for a living?GR: “I would probably be a car salesman. Beyond racing, cars, that’s probably my biggest passion. So I think I’d definitely be involved with cars no matter what.” Session ID: 2020-09-18:1ecc6b3ade80a009ade50a2a Player ID: videojs-brightcove-player-835412-4288517697001 OK Close Modal DialogCaption Settings DialogBeginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsDefaultsDoneClose Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button. Play VideoPlayMuteCurrent Time 0:00/Duration Time 0:00Loaded: 0%0:00Progress: 0%0:00 Progress: 0%Stream TypeLIVERemaining Time -0:00 Playback Rate1ChaptersChaptersdescriptions off, selectedDescriptionssubtitles off, selectedSubtitlescaptions settings, opens captions settings dialogcaptions off, selectedCaptionsAudio TrackFullscreenThis is a modal window. An unanticipated problem was encountered, check back soon and try again Error Code: MEDIA_ERR_UNKNOWNlast_img read more

Girls basketball: Benton clinches share of seventh-grade title

first_imgThe Benton Lady Tigers clinched a share of the Bossier Parish middle school seventh-grade district title with a 37-9 victory over Rusheon Thursday night at Benton.The Lady Tigers improved to 8-0 and have a two-game lead over Greenacres with two to play. Greenacres defeated Elm Grove 20-14 Monday.In the other seventh-grade game, Cope downed Haughton 34-27.Rusheon regained the lead in the eighth-grade district with a 19-11 victory over Benton.Cope knocked Haughton out of a tie for first with a 37-31 victory over the Lady Bucs. In the other eighth-grade game, Elm Grove slipped past Greenacres 16-15.Rusheon improved to 6-2 and has a one-game lead over Haughton and Elm Grove, both 5-3. Greenacres and Cope are both 4-4.At Benton, Emily Ward scored in double figures for the eighth straight game to lead the Lady Tigers seventh-graders. She had 13 points and four assists.Morgan Bradford and Madison Breazeale scored six each. Abbie Wynn and Abby Colvin played outstanding defense, coach MaryJo Duddy said.Destiny Thomas scored seven points to lead the victorious Rusheon eighth-graders.Benton’s Mackenzie McEntee and Braylin Shaffer combined for eight points.Mackenzie Terhune and Malorie Gill played tough defense, and Brittney McLelland was strong on the boards, Duddy said.At Cope, Brooklyn Brandon and Jaisha Banks scored 15 points each to lead the Lady Cougars seventh-grade team.Caitlin Ward and Ebarb had nine points each for Haughton.Chloe Walker led the victorious Cope eighth-graders with 14 points. Jasmyne Dawson added eight, Jalyn Robertson seven and Lauren Daley six.Robertson scored all of her points in the second quarter and had three big offensive rebounds. Daley also had several key rebounds.Champagne Dennis topped Haughton with 16 points, and Mayghan Myers had 10.At Elm Grove, Traciona Russell led the Greenacres seventh-graders to the victory with 14 points. Jhnaudika Cook and Zakiya Johnson combined for six.Madeline Grunewald paced Elm Grove with six points. Marianna Gonzalez, Tracilyn Bell, Shanna Abdeljabar and Natavia Anthony combined for eight.Dionisha Wilson, Kaylan Coker and Abbie Norcross all scored four points for the victorious Elm Grove eighth-graders.Greenacres’ Comuilla Rodriquez scored a game-high 13. Premier Diamond BoutiqueHong Kong’s first lab-grown diamond empirePremier Diamond Boutique|SponsoredSponsoredUndoInstant Voice TranslatorInstant Voice Translator (43 Languages) Takes Hong Kong By StormInstant Voice Translator|SponsoredSponsoredUndoPerfect-Dating.comAre You Ready to Meet Cool Guys in Tung Chung?|SponsoredSponsoredUndoStanChart by CNBC CatalystBlockchain Is Changing the Game for Trade Financing. Here’s How It’s Driving Future Global Trade.StanChart by CNBC Catalyst|SponsoredSponsoredUndoDating.comThe Most Handsome Guys In Hong Kong On This Dating|SponsoredSponsoredUndoStrategyCombatIf you own a Computer, then you have to play this Game. No Install.StrategyCombat|SponsoredSponsoredUndo Russell Hedgesrhedges@bossierpress.comlast_img read more

College basketball: BPCC’s Eric Parrish named NJCAA Division I men’s Player of the Week

first_imgCharlie CavellBPCC Athletic CoordinatorFor the second time this week, Bossier Parish Community College’s Eric Parrish has been honored for his outstanding play on the basketball court. Wednesday, the National Junior College Athletic Association named Parrish as its Division I men’s basketball Player of the Week for the week of Nov. 26 through Dec. 3.In the three games during the week, Parrish averaged 27.7 points, 9.7 rebounds and 10.0 assists per game. He registered two triple-doubles during the week, including scoring 35 points, pulling down 12 rebounds and dishing out 10 assists against Cy-Fair Learning Center. Parrish was the first Cavalier to have a triple-double since Jerry Perry accomplished the feat in 2016. He scored 17 points, grabbed 12 rebounds and doled out 10 assists on the road in the Region XIV opener for the Cavaliers versus Lamar State College – Port Arthur. Parrish, who has signed with the University of Nevada, has helped Bossier Parish get off to a 7-0 start, which is the best record for a Cavaliers team since before the 2001-02 season. BPCC plays Lee College Wednesday at 7:30 p.m. in the Coach Billy Montgomery Gym.Parrish and Louisiana-Lafayette forward Jakeenan Gant were named the college basketball co-players of the month for November by the Louisiana Sports Writers Association. Parrish, averaged 22.2 points, 10.7 rebounds, 6.2 assists and 2.0 steals per game.Premier Diamond BoutiqueHong Kong’s first lab-grown diamond empirePremier Diamond Boutique|SponsoredSponsoredUndoTheTopFiveVPNThe Secret Netflix Doesn’t Want You To Know To Unblock RestrictionsTheTopFiveVPN|SponsoredSponsoredUndoAspireAbove.comRemember Abby from NCIS? Take A Deep Breath Before You See How She Looks|SponsoredSponsoredUndoPerfect-Dating.comAre You Ready to Meet Cool Guys in Tung Chung?|SponsoredSponsoredUndoTheTopFiveVPNThe Trick Netflix Doesn’t Want You To Know To Unlock RestrictionsTheTopFiveVPN|SponsoredSponsoredUndoCelebsland.com9 Celebrity Before-And-After Plastic Surgery|SponsoredSponsoredUndolast_img read more